Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties

SJ Kim, MH Jung, KH Yoo, JH Cho, CH Oh

文献索引：Kim, Seoung Jong; Jung, Myung-Ho; Yoo, Kyung Ho; Cho, Jung-Hyuck; Oh, Chang-Hyun Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 21 p. 5815 - 5818

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被引用次数: 43

摘要

The synthesis of a new series of oxazolidinones having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram- negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound 15g having [1, 2, 5] thiadiazolidin-1, 1-dioxide moiety showed the most potent antibacterial activity.