The synthesis of a new series of oxazolidinones having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram- negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound 15g having [1, 2, 5] thiadiazolidin-1, 1-dioxide moiety showed the most potent antibacterial activity.
[Castro, Jose L.; Baker, Raymond; Guiblin, Alexander R.; Hobbs, Sarah C.; Jenkins, Matthew; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 19 p. 3023 - 3032]
