Tetrahedron

Investigations into ambient temperature biaryl coupling reactions

JC Anderson, H Namli, CA Roberts

文献索引：Anderson, James C.; Namli, Hilmi; Roberts, Craig A. Tetrahedron, 1997 , vol. 53, # 44 p. 15123 - 15134

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被引用次数: 112

摘要

An ambient temperature, unsymmetrical, biaryl coupling reaction for hindered systems based on Suzuki methodology has been developed. A description of the optimisation of this process leading to the recommendation of aqueous thallium hydroxide as base, in dimethylacetamide, with hindered boronic acids and aryl halides to achieve good to moderate yields of hindered biaryls is presented, along with an interpretation of the ...