Hydroxamic acid inhibitors of 5-lipoxygenase

JB Summers, H Mazdiyasni, JH Holms…

文献索引：Summers; Mazdiyasni; Holms; Ratajczyk; Dyer; Carter Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 574 - 580

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被引用次数: 114

摘要

The hydroxamic acid functionality can be incorporated in a variety of simple molecules to produce potent inhibitors of 5-lipoxygenase. As an example of this, the structure-activity relationships in a series of w-phenylalkyl and w-naphthylalkyl hydroxamic acids are presented. Among the features described are the influence of hydrophobicity, aryl substitution, and modifications of the hydroxamate group on enzyme inhibitory potency. To ...