Palladium??Catalyzed Synthesis of Substituted Hydantoins—A New Carbonylation Reaction for the Synthesis of Amino Acid Derivatives

…, M Eckert, WA Moradi, H Neumann

文献索引：Beller, Matthias; Eckert, Markus; Moradi, Wahed A.; Neumann, Helfried Angewandte Chemie - International Edition, 1999 , vol. 38, # 10 p. 1454 - 1457

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被引用次数: 54

摘要

Abstract One-step synthesis of substitutedhydantoins can be achieved by the palladium- catalyzed “ureidocarbonylation” of aldehydes with urea derivatives and carbon monoxide [Eq.(1)]. This surprisingly selective protocol converts substituted ureas into 1, 5-and 1, 3, 5- substituted hydantoins in yields of up to 93%.