Journal of the American Chemical Society

Absolute configuration of the trans-9, 10-dihydrodiol metabolite of the carcinogen benzo [a] pyrene

H Yagi, DM Jerina

文献索引：Yagi, Haruhiko; Jerina, Donald M. Journal of the American Chemical Society, 1982 , vol. 104, # 14 p. 4026 - 4027

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被引用次数: 30

摘要

The cytochromes P-450 are the principal enzymes in liver that are responsible for the oxidative detoxification of nonpolar foreign compounds by mammals.'Among these enzymes, cytochrome P-450c2 is particularly effective in catalyzing the oxidation of polycyclic aromatic hydrocarbons and accounts for 70% of the total cytochromes P-450 in the livers of rats that have been treated with the inducer 3-methyl~ holanthrene.~ We have ...