Design and synthesis of a series of combined vasodilator-. beta.-adrenoceptor antagonists based on 6-arylpyridazinones

RA Slater, W Howson, GTG Swayne…

文献索引：Journal of Medicinal Chemistry, , vol. 31, # 2 p. 345 - 351

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被引用次数: 26

摘要

... treatment of hypertension with a com- bination of a direct-acting vasodilator (eg, hydralazine) and a P-adrenoceptor antagonist (eg, propran~lol)~ prompted our studies aimed at designing single chemical entities possessing ... 251-266. Journal of Medicinal Chemistry, 1988, Vol ...