. omega.-[(. omega.-Arylalkyl) thienyl] alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists

R Labaudiniere, G Hilboll, A Leon-Lomeli…

文献索引：Labaudiniere, Richard; Hilboll, Gerd; Leon-Lomeli, Alicia; Terlain, Bernard; Cavy, Francoise; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3170 - 3179

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被引用次数: 13

摘要

A series of w-[(w-arylalkyl) thienyl] alkanoic acid isomers was prepared and a structure- activity relationship was investigated. These compounds have displayed either LTA, hydrolase inhibition activities or LTB, receptor binding activities, or both, depending on the relative orientation of the two side chains on the thiophene ring. Whereas the 2, 5-isomers specifically exhibited LTA, hydrolase inhibition, 3, 5-isomers displayed both activities. On ...