. omega.-[(. omega.-Arylalkyl) thienyl] alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists

R Labaudiniere, G Hilboll, A Leon-Lomeli…

Index: Labaudiniere, Richard; Hilboll, Gerd; Leon-Lomeli, Alicia; Terlain, Bernard; Cavy, Francoise; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3170 - 3179

Full Text: HTML

Citation Number: 13

Abstract

A series of w-[(w-arylalkyl) thienyl] alkanoic acid isomers was prepared and a structure- activity relationship was investigated. These compounds have displayed either LTA, hydrolase inhibition activities or LTB, receptor binding activities, or both, depending on the relative orientation of the two side chains on the thiophene ring. Whereas the 2, 5-isomers specifically exhibited LTA, hydrolase inhibition, 3, 5-isomers displayed both activities. On ...