Synthesis of new 2, 4-diaminopyrido [2, 3-d] pyrimidine and 2, 4-diaminopyrrolo [2, 3-d] pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and …

A Rosowsky, H Chen, H Fu, SF Queener

文献索引：Rosowsky, Andre; Chen, Han; Fu, Hongning; Queener, Sherry F. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 1 p. 59 - 67

全文：HTML全文

被引用次数: 87

摘要

A concise new route allowing easy access to five previously unreported 2, 4-diamino-6- (substituted benzyl) pyrido [2, 3-d] pyrimidines (2a–e) was developed, involving condensation of 2, 4-dipivaloylamino-5-bromopyrido [2, 3-d] pyrimidine (6) with an organozinc halide in the presence of a catalytic amount of [1, 1′-bis (diphenylphosphino) ferrocene] dichloropalladium (II)· CH2Cl2, followed by removal of the pivaloyl groups with ...