Polyhalogenated heterocyclic compounds: Part 52.[1] Macrocycles from 3, 5-dichloro-2, 4, 6-trifluoropyridine
RD Chambers, A Khalil, CB Murray, G Sandford…
文献索引：Chambers, Richard D.; Khalil, Ali; Murray, Christopher B.; Sandford, Graham; Batsanov, Andrei S.; Howard, Judith A.K. Journal of Fluorine Chemistry, 2005 , vol. 126, # 7 p. 1002 - 1008
Model studies show that displacement of fluorine, rather than chlorine, occurs upon reaction of 3, 5-dichloro-2, 4, 6-trifluoropyridine with sodium methoxide and phenoxide. Subsequent hydro-dechlorination can be achieved by reaction with lithium aluminium hydride whereas reaction of sodium in iso-propanol leads to formation of the tri-iso-propoxy pyridine derivative, via nucleophilic substitution of the methoxy group, rather than the ...
