Model studies show that displacement of fluorine, rather than chlorine, occurs upon reaction of 3, 5-dichloro-2, 4, 6-trifluoropyridine with sodium methoxide and phenoxide. Subsequent hydro-dechlorination can be achieved by reaction with lithium aluminium hydride whereas reaction of sodium in iso-propanol leads to formation of the tri-iso-propoxy pyridine derivative, via nucleophilic substitution of the methoxy group, rather than the ...
