Dimethyl sulfoxide as a co-solvent dramatically enhances the enantioselectivity in lipase-catalysed resolutions of 2-phenoxypropionic acyl derivatives

K Watanabe, S Ueji

文献索引：Watanabe, Keiichi; Ueji, Shin-Ichi Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 12 p. 1386 - 1390

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被引用次数: 43

摘要

We recently reported that the enantioselectivity for subtilisin-catalysed hydrolysis of ethyl 2- (4-substituted phenoxy) propionates in aqueous buffer is found to be dramatically enhanced by addition of dimethyl sulfoxide (DMSO). In our present work, as one of the useful methods for improving the enzyme's enantioselectivity, this approach using DMSO is tested for both hydrolysis and transesterification catalysed by various lipases. For instance, for Candida ...