Tetrahedron

Highly stereoselective titanium-mediated aldol reactions from chiral α-silyloxy ketones. A reliable tool for the synthesis of natural products

J Esteve, C Jiménez, J Nebot, J Velasco, P Romea…

文献索引：Esteve, Judit; Jimenez, Carme; Nebot, Joaquim; Velasco, Javier; Romea, Pedro; Urpi, Flix Tetrahedron, 2011 , vol. 67, # 33 p. 6045 - 6056

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被引用次数: 13

摘要

Chiral α-silyloxy ketones participate in highly stereoselective TiCl4-mediated aldol reactions that afford diastereomerically pure syn–syn adducts in high yield irrespective of the R1 and R2 substituents flanking the carbonyl or the silicon protecting group. Further manipulation of the resulting aldol adducts provide in a straightforward manner highly functionalized fragments that facilitate the synthesis of natural products.