First asymmetric synthesis of the marine furanosesterterpene natural product,(18S)-variabilin, employing enzymatic desymmetrization of propanediol derivatives

K Takabe, H Hashimoto, H Sugimoto, M Nomoto…

文献索引：Takabe, Kunihiko; Hashimoto, Hiroya; Sugimoto, Hideki; Nomoto, Masaru; Yoda, Hidemi Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 909 - 912

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被引用次数: 34

摘要

Variabilin 1, a unique furanosesterterpene tetronic acid of marine origin, was first isolated in 1973 by Faulkner 1 from the sponge, Ircinia variabilis, and subsequently from Sarcotragus sp. 2 in research for potential antiviral antitumor agents from marine invertebrates. Closely related linear sesterterpenes containing one or two furan units together with a conjugated tetronic acid moiety, ircinin-1 2, ircinin-2 3 and fasciculatin 4 were also isolated by Minale and ...