Tetrahedron letters

A facile microwave-assisted palladium-catalyzed cyanation of aryl chlorides

HR Chobanian, BP Fors, LS Lin

文献索引：Chobanian, Harry R.; Fors, Brett P.; Lin, Linus S. Tetrahedron Letters, 2006 , vol. 47, # 19 p. 3303 - 3305

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被引用次数: 73

摘要

We report an efficient method for the preparation of aryl nitriles from aryl chlorides under either microwave assisted or thermal conditions. A catalyst system comprising tris (dibenzylidene acetone) dipalladium (Pd2 (dba) 3) and 2-(2′, 6′-dimethoxybiphenyl) dicyclohexylphosphine (S-Phos) is shown to effectively promote cyanation of various aryl chlorides with Zn (CN) 2 as the cyanide source.