Il Farmaco

A new alternative synthesis of 5-cyanophthalide, a versatile intermediate in the preparation of the antidepressant drug citalopram

F Micheli, L Crippa, D Donati, R Di Fabio, C Leslie

文献索引：Micheli, Fabrizio; Crippa, Luca; Donati, Daniele; Di Fabio, Romano; Leslie, Colin Farmaco, 2001 , vol. 56, # 9 p. 715 - 718

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被引用次数: 2

摘要

An alternative versatile synthesis of 5-cyanophthalide, a key synthetic intermediate in the preparation of the antidepressant drug Citalopram, is presented. The synthesis reported here allows the preparation of this important intermediate in three steps, avoiding the manipulation of environmentally detrimental cyanides.