Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3, 4, 5-trisphosphate and D-myo-inositol 1, 5, 6-trisphosphate: aspects of their structure-activity …
Unambiguous total syntheses of both optical antipodes of the enantiomeric pair d-myo- inositol 3, 4, 5-trisphosphate (Ins (3, 4, 5) P3) and d-myo-inositol 1, 5, 6-trisphosphate (Ins (1, 5, 6) P3) are described. The ring system characteristic of myo-inositol was constructed de novo from p-benzoquinone. X-ray data for the enzymatically resolved (1 S, 2 R, 3 R, 4 S)-1, 4- diacetoxy-2, 3-dibromocyclohex-5-ene enabled the unequivocal assignment of the ...
