Tetrahedron: Asymmetry

A new resolution of (1α, 2β, 3α, 4β)-2, 3-dibromocyclohex-5-en-1, 4-diol by lipase from Mucor miehei

C Sanfilippo, A Patti, G Nicolosi

文献索引：Sanfilippo, Claudia; Patti, Angela; Nicolosi, Giovanni Tetrahedron Asymmetry, 2000 , vol. 11, # 5 p. 1043 - 1045

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被引用次数: 10

摘要

Resolution of (±)-1 has already been achieved by enantioselective hydrolysis of ester (±)-2 in the presence of Pseudomonas cepacia lipase. 5 However, the concomitant spontaneous hydrolysis occurring in water has a detrimental effect on the enantiomeric purity of the products, making this unsuitable for preparative purposes. We thought this disadvantage could be avoided by the use of biocatalytic procedures, alcoholysis and esterification, operating in an organic ...