Tetrahedron

Asymmetric syntheses of (S)-fenfluramine using sharpless epoxidation methods

B Goument, L Duhamel, R Mauge

文献索引：Goument, Bertrand; Duhamel, Lucette; Mauge, Robert Tetrahedron, 1994 , vol. 50, # 1 p. 171 - 188

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被引用次数: 18

摘要

We describe one synthesis of (S)-fenfluramine and several syntheses of its precursors (R)- and (S)-1-(metatrifluoromethylphenyl) propan-2-ols. They were obtained from the asymmetric epoxidation of the primary allylic alcohol 5 and from the kinetic resolution with asymmetric epoxidation of the secondary allylic alcohol 6.