Tetrahedron

Asymmetric syntheses of (S)-fenfluramine using sharpless epoxidation methods

B Goument, L Duhamel, R Mauge

Index: Goument, Bertrand; Duhamel, Lucette; Mauge, Robert Tetrahedron, 1994 , vol. 50, # 1 p. 171 - 188

Full Text: HTML

Citation Number: 18

Abstract

We describe one synthesis of (S)-fenfluramine and several syntheses of its precursors (R)- and (S)-1-(metatrifluoromethylphenyl) propan-2-ols. They were obtained from the asymmetric epoxidation of the primary allylic alcohol 5 and from the kinetic resolution with asymmetric epoxidation of the secondary allylic alcohol 6.