The Journal of organic chemistry

An inexpensive air-stable titanium-based system for the conversion of esters to primary alcohols

MT Reding, SL Buchwald

文献索引：Reding, Matthew T.; Buchwald, Stephen L. Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7884 - 7890

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被引用次数: 62

摘要

Results The results of a series of reactions between functionalized methyl and ethyl esters 1 and 2.5 equiv PMHS (monomer weight= 60) in the presence of varying amounts of Ti (OiPrI4 are presented in Table 1 (see Scheme 1). These reactions were carried out simply by mixing together the neat reagents in an ordinary test tube open to the ambient atmosphere; only a calcium sulfate drying tube was used to exclude atmospheric moisture. Often, but not ...