Organic letters

An outside-in approach to adjacent bistetrahydrofuran annonaceous acetogenins with C 2 core symmetry. Total synthesis of asimicin and a C32 analogue

JA Marshall, JJ Sabatini

文献索引：Marshall, James A.; Sabatini, Jesse J. Organic Letters, 2006 , vol. 8, # 16 p. 3557 - 3560

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被引用次数: 43

摘要

The goal of the present study was to develop a convergent route to a single-core segment of the threo,trans,threo,trans, threo stereochemistry, present in asimicin and a number of other highly cytotoxic natural acetogenins (Figure 1), 8 with a view to prepare various analogues differing in the length and nature of the pendant side chains. We were motivated to pursue this line of investigation by a report of Miyoshi and co-workers who concluded from molecular ...