4-amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-adenosylmethionine decarboxylase

…, J Frei, P Furet, H Mett, P Schneider…

文献索引：Stanek; Caravatti; Frei; Furet; Mett; Schneider; Regenass Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2168 - 2171

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被引用次数: 49

摘要

S-Adenosylmethionine decarboxylase (SAMDC) is a rate-limiting enzyme of polyamine (PA) biosynthesis which controls the conversion of the diamine putrescine to the higher polyamines spermidine and spermine.'SAMDC represents a therapeutic target for rapidly proliferating cells which have up to 3 orders of magnitude higher specific activity of PA biosynthetic enzymes and larger polyamine pools and are generally more sensitive to ...