Model compound 3 in which the protected guanosine moiety is linked to the carcinogen (N- acetyl-N-hydroxy)-2-aminofluorene has been prepared and studied in various solvolytic conditions. The intramolecular reaction leads notably to the arylamidation of the guanine ring by the carcinogen.
![2-acetamido-9H-fluoren-1-yl (((3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1H-purin-9(6H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl) succinate结构式](https://image.chemsrc.com/caspic/024/137390-97-7.png)