Tetrahedron

Arylamidation de la guanosine par un agent cancérogène, le 2-aminofluorène. Approche intramoléculaire.

E Defrancq, A Leterme, N Pelloux, MF Lhomme…

文献索引：Defrancq, Eric; Leterme, Anne; Pelloux, Nadia; Lhomme, Marie-France; Lhomme, Jean Tetrahedron, 1991 , vol. 47, # 30 p. 5725 - 5736

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被引用次数: 11

摘要

Model compound 3 in which the protected guanosine moiety is linked to the carcinogen (N- acetyl-N-hydroxy)-2-aminofluorene has been prepared and studied in various solvolytic conditions. The intramolecular reaction leads notably to the arylamidation of the guanine ring by the carcinogen.