Bioorganic & medicinal chemistry letters

Rational design of antimicrobial agents: antifungal activity of alk (en) yl dihydroxybenzoates and dihydroxyphenyl alkanoates

K Nihei, A Nihei, I Kubo

文献索引：Nihei, Ken-Ichi; Nihei, Atsuko; Kubo, Isao Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3993 - 3996

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被引用次数: 24

摘要

A homologous series (C3–C14) of each alkyl 3, 4-and 3, 5-dihydroxybenzoates, and 3, 4- and 3, 5-dihydroxyphenyl alkanoates exhibit similar antifungal activity against Saccharomyces cerevisiae. Their nonyl derivatives exhibit the most potent antifungal activity against this yeast with the minimum fungicidal concentration (MFC) in the range between 12.5 and 50 μg/mL. In addition, various 3, 4-dihydroxybenzoates, possessing different ...