Bioorganic & medicinal chemistry letters

Rational design of antimicrobial agents: antifungal activity of alk (en) yl dihydroxybenzoates and dihydroxyphenyl alkanoates

K Nihei, A Nihei, I Kubo

Index: Nihei, Ken-Ichi; Nihei, Atsuko; Kubo, Isao Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3993 - 3996

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Citation Number: 24

Abstract

A homologous series (C3–C14) of each alkyl 3, 4-and 3, 5-dihydroxybenzoates, and 3, 4- and 3, 5-dihydroxyphenyl alkanoates exhibit similar antifungal activity against Saccharomyces cerevisiae. Their nonyl derivatives exhibit the most potent antifungal activity against this yeast with the minimum fungicidal concentration (MFC) in the range between 12.5 and 50 μg/mL. In addition, various 3, 4-dihydroxybenzoates, possessing different ...