Tetrahedron

Tricyclic isoindolines by Heck cyclization

G Satyanarayana, ME Maier

文献索引：Satyanarayana, Gedu; Maier, Martin E. Tetrahedron, 2012 , vol. 68, # 6 p. 1745 - 1749

全文：HTML全文

被引用次数: 13

摘要

A series of 4-formyl esters 8a–d was prepared by Michael addition of an enamine with ethyl acrylate. A subsequent condensation with 2-bromobenzylamines 3 gave rise to cyclic enamides 9aa–dd. In a Heck cyclization reaction tricyclic isoindoles 10aa–dd were formed in good yields.