Journal of the American Chemical Society

A hybrid phosphorus ligand for highly enantioselective asymmetric hydroformylation

Y Yan, X Zhang

文献索引：Yan, Yongjun; Zhang, Xumu Journal of the American Chemical Society, 2006 , vol. 128, # 22 p. 7198 - 7202

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被引用次数: 147

摘要

Today, hydroformylation is the largest industrially homogeneous catalytic process. Over 6 million tons of oxo products are being produced worldwide per year. Because chiral aldehydes can be easily converted into a variety of enantiomerically pure compounds, asymmetric hydroformylation 1 is potentially useful for the preparation of pharmaceutical products. Despite its importance, asymmetric hydroformylation is underdeveloped. Achieving high ee's (≥98% ee) remains ...