Discovery of 4-Amino-N-[(1 S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7 H-pyrrolo [2, 3-d] pyrimidin-4-yl) piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, …

M Addie, P Ballard, D Buttar, C Crafter…

文献索引：Journal of Medicinal Chemistry, , vol. 56, # 5 p. 2059 - 2073

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被引用次数: 34

摘要

... Journal of Medicinal Chemistry. ... kinases. Due to the strong rationale for targeting Akt in cancer, much effort has been made to identify Akt inhibitors with acceptable pharmaceutical properties, particularly for oral dosing. ...