Discovery of 4-Amino-N-[(1 S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7 H-pyrrolo [2, 3-d] pyrimidin-4-yl) piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, …

M Addie, P Ballard, D Buttar, C Crafter…

Index: Journal of Medicinal Chemistry, , vol. 56, # 5 p. 2059 - 2073

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Citation Number: 34

Abstract

... Journal of Medicinal Chemistry. ... kinases. Due to the strong rationale for targeting Akt in cancer, much effort has been made to identify Akt inhibitors with acceptable pharmaceutical properties, particularly for oral dosing. ...