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Medicinal Chemistry Research

DABCO-promoted one-pot synthesis of heteroaryl-substituted benzenes and their biological evaluation

GN Babu, HM Ayalew, S Jain

文献索引:Babu, G. Neelaiah; Ayalew, Haile Micheal; Jain, Shubha Medicinal Chemistry Research, 2014 , vol. 23, # 5 p. 2608 - 2614

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被引用次数: 0

摘要

Abstract A simple and efficient one-pot synthesis of heteroaryl-substituted benzenes has been developed via cyclocondensation of vinylmalononitriles and ethylvinylcyanoacetates with heteroarylnitroolefines using diazabicyclo [2, 2, 2] octane as catalyst. The titled compounds were evaluated for their antitubercular, antibacterial and antifungal activities at various concentrations.