Visible light excitable Zn2+ fluorescent sensor derived from an intramolecular charge transfer fluorophore and its in vitro and in vivo application

F Qian, C Zhang, Y Zhang, W He, X Gao…

文献索引：Qian, Fang; Zhang, Changli; Zhang, Yumin; He, Weijiang; Guo, Zijian; Gao, Xiang; Hu, Ping Journal of the American Chemical Society, 2009 , vol. 131, # 4 p. 1460 - 1468

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被引用次数: 292

摘要

The UV-and sensor-induced interferences to living systems pose a barrier for in vivo Zn2+ imaging. In this work, an intramolecular charge transfer (ICT) fluorophore of smaller aromatic plane, 4-amino-7-nitro-2, 1, 3-benzoxadiazole, was adopted to construct visible light excited fluorescent Zn2+ sensor, NBD-TPEA. This sensor demonstrates a visible ICT absorption band, a large Stokes shift, and biocompatibility. It emits weakly (Φ= 0.003) without pH ...