Divergent Synthesis and Evaluation of Inhibitory Activities against Cyclooxygenases-1 and-2 of Natural Withasomnines and Analogues

Y Usami, R Watanabe, Y Fujino, M Shibano…

文献索引：Usami, Yoshihide; Watanabe, Ryo; Fujino, Yuiko; Shibano, Makio; Ishida, Chihiro; Yoneyama, Hiroki; Harusawa, Shinya; Ichikawa, Hayato Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 12 p. 1550 - 1560

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被引用次数: 3

摘要

The divergent synthesis of natural withasomnines and analogues was achieved from 4- hydroxypyrazoles, which was prepared via alkaline hydrolysis of the Baeyer–Villiger oxidation products from 4-formylpyrazoles. Key steps of this synthesis are regioselective Claisen rearrangement of 4-allyloxypyrazoles and the Suzuki–Miyaura coupling of 5, 6- dihydro-4H-pyrrolo [1, 2-b] pyrazol-3-yl trifluoromethanesulfonate and commercially ...