The table illustrates that the benzyl triflates provide it versatile synthesis ol" N-[4-chloro-2- fiuoro-5-(substituted methyl) phenyljimides. The triflate moiety is readily displaced by weak nucleophiles allowing the C5 methylene to be substituted by alkoxy. alkylthio. alkylamino, glucosidic. glycolic. and even electron-rich aromatic groups. The procedure may be easily applied to the synthesis of multi-gram samples of the imides. A number of improvements to ...
