Synthesis

Novel N-[4-Chloro-2-fluoro-5-(substituted methyl) phenyl] imides

TN Wheeler, TA Craig, RB Morland, JA Ray

Index: Wheeler, Thomas N.; Craig, Todd A.; Morland, Robert B.; Ray, John, A. Synthesis, 1987 , # 10 p. 883 - 887

Full Text: HTML

Citation Number: 2

Abstract

The table illustrates that the benzyl triflates provide it versatile synthesis ol" N-[4-chloro-2- fiuoro-5-(substituted methyl) phenyljimides. The triflate moiety is readily displaced by weak nucleophiles allowing the C5 methylene to be substituted by alkoxy. alkylthio. alkylamino, glucosidic. glycolic. and even electron-rich aromatic groups. The procedure may be easily applied to the synthesis of multi-gram samples of the imides. A number of improvements to ...