Benzylphosphonic acid inhibitors of human prostatic acid phosphatase

…, SA Beers, EA Malloy, JJ Cinicola, DJ Wustrow…

文献索引：Schwender; Beers; Malloy; Cinicola; Wustrow; Demarest; Jordan Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 3 p. 311 - 314

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被引用次数: 10

摘要

A series of α-substituted benzylphosphonic acids is described as inhibitors of human prostatic acid phosphatase, an enzyme which has been used as a model to study aryl phosphatases. The most potent inhibitors in this series are 2- trifluoromethylbenzhydrylphosphonic acid (9 μM), and α-(2-phenylethyl) benzylphosphonic acid (14 μM). The structure-activity studies suggest that bulk tolerance beyond the ...