Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from Cryptosporidium
DB Bolstad, ESD Bolstad, KM Frey…
文献索引：Bolstad, David B.; Bolstad, Erin S. D.; Frey, Kathleen M.; Wright, Dennis L.; Anderson, Amy C. Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6839 - 6852
Cryptosporidiosis is an emerging infectious disease that can be life-threatening in an immune-compromised individual and causes gastrointestinal distress lasting up to 2 weeks in an immune-competent individual. There are few therapeutics available for effectively treating this disease. We have been exploring dihydrofolate reductase (DHFR) as a potential target in Cryptosporidium. On the basis of the structure of the DHFR enzyme from C. ...
