Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl) benzyl) piperidines and related compounds

…, JM Arrang, JC Schwartz, W Schunack…

文献索引：Sasse, Astrid; Ligneau, Xavier; Sadek, Bassem; Elz, Sigurd; Pertz, Heinz H.; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger Archiv der Pharmazie, 2001 , vol. 334, # 2 p. 45 - 52

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被引用次数: 36

摘要

In an extension of very recently published studies on successful imidazole replacements in some series of histamine H3 receptor antagonists, we report on a new class of lipophilic nonimidazole antagonist having an aliphatic tertiary amino moiety connected to a benzyl template substituted in the 4-position by a phenoxymethyl group. The structural modifications were performed with the intention to avoid possible negative side effects ...