An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic …
GM Dubowchik, JA Michne, D Zuev
文献索引：Dubowchik, Gene M.; Michne, Jodi A.; Zuev, Dmitry Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3147 - 3149
Collections of small secondary amines for compound library generation can be efficiently prepared by amide reduction using BH3–THF or Red-Al followed by brief methanolysis, trapping with di-tert-butyl dicarbonate, and deprotection with 4M HCl in dioxane. The sequence requires no chromatography or distillation and provides multi-gram quantities of pure HCl salts in a short time.
