Tetrahedron letters

Efficient synthesis of tertiary amines from secondary amines

M Kurosu, SS Dey, DC Crick

文献索引：Kurosu, Michio; Dey, Sevendu Sekhar; Crick, Dean C. Tetrahedron Letters, 2006 , vol. 47, # 28 p. 4871 - 4875

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被引用次数: 9

摘要

Reliable N-alkylations of secondary amines have been developed. By using DIAD and TPP (or PS-TPP) a variety of secondary amines can be converted to the corresponding tertiary amines in good to excellent yields with diverse alkylhalides; no formation of quaternary amine salts are observed. These protocols are amenable to combinatorial chemistry libraries, and are also useful for the syntheses of secondary amines by an acid lysis of the ...