Synthesis of 1-azabicyclo [3.3. 0] octane derivatives and their effects as piracetam-like nootropics.

M Oka, Y Matsumoto, K Hirooka, T SUZUKI

文献索引：Oka; Matsumoto; Hirooka; Suzuki Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 8 p. 1121 - 1124

全文：HTML全文

被引用次数: 9

摘要

A useful pharmaceutical intermediate, 5-nitromethyl-1-azabicyclo [3.3. 0] octane (1), was prepared in one step from 1, 7-dichloro-4-heptanone (4) under mild conditions. Catalytic hydrogenation of 1 over Raney Ni in the presence of sodium hydroxide afforded 5-