Synthesis of 7a??substituted benzoylaminoalkyl??hexahydro??1H??pyrrolizines and evaluation of their antiarrhythmic activity

…, M Hayashimatsu, F Satoh, K Sumoto

文献索引：Miyano; Shima; Hayashimatsu; Satoh; Sumoto Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 5 p. 416 - 418

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被引用次数: 2

摘要

Abstract Several 7a-substituted benzoylaminoalkyl-hexahydro-1H-pyrrolizines were synthesized by acylations of 7a-aminoalkyl-hexahydro-1 H-pyrrolizines. All compounds synthesized were evaluated for their antiarrhythmic activities using the chloroform-mouse method, and some of them were found to have significant antiarrhythmic activities, comparable to that of procainamide.