Synthesis and inhibition study of monoamine oxidase, indoleamine 2, 3-dioxygenase and tryptophan 2, 3-dioxygenase by 3, 8-substituted 5H-indeno [1, 2-c] pyridazin …

J Reniers, C Meinguet, L Moineaux, B Masereel…

文献索引：Reniers; Meinguet; Moineaux; Masereel; Vincent; Frederick; Wouters European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 6104 - 6111

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被引用次数: 12

摘要

Previous studies on 5H-indeno [1, 2-c] pyridazin-5-one derivatives as inhibitors of MAO-B revealed that it was possible to increase the MAO-B inhibitory potency of 5H-indeno [1, 2-c] pyridazin-5-ones by substituting the central heterocycle in the 3-position or C-8 with lipophilic groups which occupy the substrate cavity or the entrance of the binding site, respectively. Here, four new 5H-indeno [1, 2-c] pyridazin-5-one derivatives containing ...