Hydroxy-1-aminoindans and derivatives: Preparation, stability, and reactivity

Y Herzig, L Lerman, W Goldenberg…

文献索引：Herzig, Yaacov; Lerman, Lena; Goldenberg, Willy; Lerner, David; Gottlieb, Hugo E.; Nudelman, Abraham Journal of Organic Chemistry, 2006 , vol. 71, # 11 p. 4130 - 4140

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被引用次数: 21

摘要

The chemical stability and reactivity of hydroxy-1-aminoindans and their N-propargyl derivatives are strongly affected by the position of the OH group and its orientation relative to that of the amino moiety. Thus, the 4-and 6-OH regioisomers were found to be stable, while the 5-OH analogues were found to be inherently unstable as the free bases. The latter, having a para orientation between the OH and the amino moieties, could be isolated only ...