Tetrahedron

Bifunctional antitumor agents. Derivatives of pyrrolo [9, 10-b] phenanthrene—A DNA intercalative delivery template

GB Jones, JE Mathews

文献索引：Jones, Graham B.; Mathews, Jude E. Tetrahedron, 1997 , vol. 53, # 43 p. 14599 - 14614

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被引用次数: 17

摘要

The preparation and intercalative ability of the pyrrolo [9, 10-b] phenanthrene nucleus is described. Functionalization of the nucleus was achieved using standard indole chemistry. The utility of this template as a DNA intercalating drug delivery system is demonstrated by synthesis of a derived bis-chloroethylamine alkylating system and a hybrid DNA interactive enediyne system.