Difluorocarbene induced facile synthesis of chlorohydrins from glycidyl ethers

S Singh, PS Bhadury, M Sharma…

文献索引：Singh, Sapna; Bhadury, Pinaki S.; Sharma, Mamta; Palit, Meehir; Jaiswal, Devendra K. Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1249 - 1253

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被引用次数: 1

摘要

A novel and unusual approach based on a ClCF2COONa DMF system has been developed for the synthesis of chlorohydrins via an unexpected mechanism. In a first ever report for the synthesis of chlorohydrins from glycidyl ethers, eg, CH2= CH-CH2-OZ, CH3CH2-OZ, C6H5- OZ, C6H4 (o-CH3)-OZ, CH2= C (CH3) C (= O)-OZ, etc.,(where Z= glycidyl), difluorocarbene- induced facile regioselective ring opening of epoxides has generated the compound in ...