Bioorganic & medicinal chemistry

Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide incorporating 7-deazaguanine bases

ML Jain, TC Bruice

文献索引：Jain, Moti L.; Bruice, Thomas C. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7333 - 7346

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被引用次数: 14

摘要

DNG nucleotides represent a positively charged DNA analog in which the negatively charged phosphodiester linkages of DNA are replaced by positively charged guanidinium linkages. We report herein the synthesis of 3′-end, middle, and 5′-end monomers required for the synthesis of a DNG sequence in which the natural guanine base is replaced by 7-deazaguanine (c7G). 7-Deazaguanine nucleobase was chosen because of their ...