Large-scale preparation of (9Z, 12E)-[1-13 C]-octadeca-9, 12-dienoic acid,(9Z, 12Z, 15E)-[1-13 C]-octadeca-9, 12, 15-trienoic acid and their [1-13 C] all-cis isomers

…, A Maret, D Poullain, JM Chardigny, JL Sébédio…

文献索引：Loreau; Maret; Poullain; Chardigny; Sebedio; Beaufrere; Noel Chemistry and Physics of Lipids, 2000 , vol. 106, # 1 p. 65 - 78

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被引用次数: 14

摘要

Several grams of labelled trans linoleic and linolenic acids with high chemical and isomeric purities (> 97%) have been prepared for human metabolism studies. A total of 12.5 g of (9Z, 12E)-[1-13C]-octadeca-9, 12-dienoic acid and 6.3 g of (9Z, 12Z, 15E)-[1-13C]-octadeca-9, 12, 15-trienoic acid were obtained in, respectively, seven steps (7.8% overall yield) and 11 steps (7% overall yield) from 7-bromo-heptan-1-ol. The trans bromo precursors used for ...