Tetrahedron letters

Enantiomeric syntheses of 6 (R), 7 (R) and 6 (S), 7 (S) trans-and cis-laurediol

B Anorbe, VS Martin, JM Palazón, JM Trujillo

文献索引：Anorbe, B.; Martin, V. S.; Palazon, J. M.; Trujillo, J. M. Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4991 - 4994

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被引用次数: 27

摘要

RT, 14 hrs.; iii)HCl (conc.) (cat.), MeOH, RT, 10 hrs., 92% overall yield; b) i)LiAlH 4 , THF, reflux, 2 hrs. 87%; ii)Br 3 P, pentane, 0°C, 0.5 hr., 78%; c) i)BrMgC ≡ CCH 2 OTHP, THF, Cu 2 Cl 2 (cat.), O°C reflux, 4 hrs.; ii) (C 6 H 5 ) 3 PBr + Br − , CH 2 Cl 2 , RT, 74%; d) BrMgC≡CCH 2 OTHP, THF, Cu 2 Cl 2 (cat.), Me 2 S, 0°C reflux, 4 hrs., 83%; e) i)HCl (conc) (cat.), MeOH, RT, 5 hrs.; ii)LiAlH 4 , ether, RT, 14 hrs., 81% overall yield. ... The optical purities of all the ...